Personizing Medicine

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Submitted By ostroffd7
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Personalizing Medicine
Daniel Ostroff

I believe it is absolutely essential to take steps to further personalize medicine. There are too many generalized treatments that may work for most patients, but still a great many patients with slight irregularities are not eligible because of these slight differences. For example, research is being done at the BIO5 Institute at the University of Arizona by Dr. Jonathan VandeGeest and his laboratory to switch the commonly used generalized metallic stents to treat an aortic aneurysm to custom manufactured Functional (due to the use of dendrimers for drug delivery) Polymeric Endoluminal Paving prototypes. The development of these customized prototypes for aneurysm patients is a massive step forward in personalized medicine. The traditional procedure to correct this condition involved complex open-chest surgery. Depending on the size and growth rate of the aneurysm, surgery can take many hours and may require multiple return visits. During surgery, the two traditional treatments are aortic grafts or metallic stents. The grafts are a wire mesh that is sewn into place to prevent further growth and leaking, which involves an extremely dangerous and invasive procedure. Otherwise, a generalized metallic stent is used, but because this device is pre-formed, it will only fit a select group of patients whose aorta is in a straight and vertical orientation. Any other shape and the treatment couldn’t be applied. Though, because the aorta is almost never perfectly straight, slips of the stent are likely to occur. Once a slip does occur, the probability for a leak is greatly enhanced. If a leak does develop, the graft loses its purpose and if a refitting surgery is not preformed, the consequences can be fatal. Both the stents and grafts may require refitting procedures and patients…...

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