Osteogenesis Imperfecta

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Student Examination into the Causes, Treatment, and Prognosis of Osteogenesis Imperfecta
Anitra Swann
Baltimore City Community College
Professor McNair
AH 130
October 18, 2011

Abstract
Osteogenesis Imperfecta is a heritable disorder of bone formation resulting in low bone mass and a propensity to fracture. It exhibits a broad range of clinical severity, ranging from multiple fracturing in utero and perinatal deaths to normal adult stature and a low fracture incidence. The disorder is currently classified into seven types based on differences in bone architecture. In addition to its primary effect on the skeletal system, the alterations in connective tissue may affect several extra skeletal structures, such as the cardiovascular system, sclera, middle and inner ear, tendons/ligaments, and central nervous system. Patients with Osteogenesis Imperfecta also have a greater incidence of airway anomalies, cardiovascular anomalies, and increased incidence of perioperative bleeding, easily fractured bones and teeth. Treatment of Osteogenesis Imperfecta by bisphosphonate therapy can improve bone mass in all types of the disorder, and while not being a cure for the disorder does improve the quality of life of the patient. This paper will examine the causes, treatment, and prognosis of Osteogenesis Imperfecta.

Student Examination into the Causes, Treatment, and Prognosis of Osteogenesis Imperfecta Osteogenesis Imperfecta (OI) is an abnormally brittle bone disease that is inherited. The term Osteogenesis Imperfecta means “imperfect bone formation.” Individuals who have OI suffer from short stature, scoliosis, thin skin, and hearing loss. Numerous fractures are common, and can occur before birth. This disorder affects six-to-seven per 100 thousand people worldwide. There are seven forms of OI. The types can be distinguished by their signs and symptoms, even…...

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